It contains 180 mg of bempedoic acid. THIS PHARMACY IS DULY LICENSED IN THE PROVINCE OF BRITISH COLUMBIA, CANADA BY THE COLLEGE OF PHARMACISTS OF BC. IF YOU HAVE ANY QUESTIONS OR CONCERNS YOU CAN CONTACT THE COLLEGE AT: 200-1765 WEST 8TH AVE VANCOUVER, BC V6J 5C6 CANADA. A less common but more serious adverse effect was tendon rupture in the rotator cuff of the shoulder, the biceps tendon or the Achilles tendon (0.5% versus 0.0%). The medication you requested Nexletol is not available. [2], Bempedoic acid was approved for use in the United States in February 2020, and for use in the European Union in April 2020. [1], In the EU, bempedoic acid is indicated in adults with primary hypercholesterolaemia (heterozygous familial and non familial) or mixed dyslipidaemia, as an adjunct to diet in combination with a statin or statin with other lipid-lowering therapies in patients unable to reach LDL C goals with the maximum tolerated dose of a statin; or alone or in combination with other lipid-lowering therapies in patients who are statin intolerant, or for whom a statin is contraindicated. Can I take NEXLETOL with other medicines? It works by reducing the amount of cholesterol made by the liver. New-onset diabetes/hyperglycemia occurred less frequently with bempedoic acid vs … Before taking NEXLETOL, tell your doctor … Bempedoic acid is used along with a proper diet and other medications to help lower "bad" cholesterol (such as LDL) in the blood. Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia (high blood cholesterol levels). [3][10][11][12] The U.S. Food and Drug Administration (FDA) granted the approval of Nexletol to Esperion Therapeutics. [2], In February 2020, bempedoic acid was approved for use in the United States. [1] About a fifth of the substance is reversibly converted by an aldo-keto reductase enzyme to a metabolite (called ESP15228) that is also pharmacologically active in form of its coenzyme A–thioester. It is activated to the thioester with coenzyme A by the enzyme SLC27A2 in the liver. [9] Bempedoic acid was approved for use in the European Union in April 2020. PRESCRIPTION DRUGS | service toll free 1.877.745.9217, or send an email to ALL PRICES ARE IN US DOLLARS. [4], Following oral intake, bempedoic acid reaches highest blood plasma concentrations after 3.5 hours. POLICIES. Bempedoic acid is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor. [13], 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid, InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24), Committee for Medicinal Products for Human Use, "Nexletol- bempedoic acid tablet, film coated", "Bempedoic Acid (ETC-1002): An Investigational Inhibitor of ATP Citrate Lyase", "Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol", "Bempedoic Acid a Small Molecule Drug Process and Synthesis, Innovation And /Or Advantages, Development Status And /Or Regulatory Status", "Esperion Announces FDA Approval of Nexletol (bempedoic acid) Tablet, an Oral, Once-Daily, Non-Statin LDL-Cholesterol Lowering Medicine", "FDA Approves Drug That Lowers Cholesterol in a New Way", "FDA approves first non-statin pill to treat high cholesterol in almost two decades", Magnesium pyridoxal 5-phosphate glutamate, https://en.wikipedia.org/w/index.php?title=Bempedoic_acid&oldid=984339755, Articles containing unverified chemical infoboxes, Articles containing potentially dated statements from March 2019, All articles containing potentially dated statements, Creative Commons Attribution-ShareAlike License, This page was last edited on 19 October 2020, at 16:13. These laboratory abnormalities were apparent by week 4, stable over time, and reversible after treatment cessation. [13] Neither the subjects nor the health care providers knew which treatment was being given. PHARMACY MANAGER: Mohammed Hassan [13] In both trials, subjects were randomly assigned to receive bempedoic acid or placebo tablets every day for 52-weeks. [1], The FDA approved bempedoic acid based on evidence from two clinical trials (Trial 1/ NCT02666664 and Trial 2/NCT02991118) of 3009 subjects with high LDL cholesterol and known atherosclerotic cardiovascular disease or HeFH. The effect is most pronounced with simvastatin and pravastatin, whose AUC is increased about twofold. Bempedoic acid (ETC-1002), a small molecule drug, promotes low density lipoprotein (LDL) receptor mediated clearance of LDL-cholesterol (LDL-C) by inhibition of adenosine triphosphate citrate lyase (ACL), a mechanism complementary to those of existing lipid-modifying therapies. [1][2], Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. NEXLETOL is a tablet that you take by mouth. [13] The trial designs were similar. Nexletol (Bempedoic Acid) is used along with a proper diet and other lipid-lowering medications to treat high cholesterol. [1], In a study, it reduced LDL cholesterol by about 20 mg/dl compared to placebo and had no more side effects than placebo, although a higher percentage of drug receiving subjects dropped out of the study because of side effects (11% vs. 7% under placebo). [1] Food does not affect its absorption. [6], In January 2020, the Committee for Medicinal Products for Human Use (CHMP) in the European Union recommended granting of a marketing authorization for bempedoic acid as both a standalone drug (Nilemdo)[8] and as a combination drug with ezetimibe (Nustendi). Bempedoic acid is an alpha,omega-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. Gout incidence was 1.6/100 vs 0.5/100 PY in the bempedoic acid vs placebo groups. OTC DRUGS | [13] The trials were conducted in United States, Canada, and Europe. [5][6], The substance also activates AMP-activated protein kinase, but this effect is likely not relevant in humans. PRESCRIPTIONS DISPENSED FROM CANADA ARE DISPENSED BY: CANDRUG PHARMACY, ID#18985 604-543-8711. [13] All enrolled subjects were on a low cholesterol diet and taking the highest dose of a statin (drug commonly used to lower cholesterol), for high cholesterol. [1], Bempedoic acid has a biological half-life of 21±11 hours. [13], The trials measured percent change in LDL-C blood levels from baseline to week 12 and compared bempedoic acid to placebo. Bempedoic acid was associated with mild increases in blood urea nitrogen, creatinine, and uric acid and decreases in hemoglobin. All rights reserved. [5] As of March 2019[update], its effects on cardiovascular morbidity and mortality have not been determined; but studies are under way. No other clinically relevant interactions have been found in studies. Copyright © 2003 - 2020 Canadian Pharmacy King. [1], Bempedoic acid is a prodrug. [1] Of ESP15228, 99.2% are bound to plasma proteins. Despite this, the drug increases blood levels of statins. [1] Over 95% of the substance are excreted in form of metabolites; about 70% with the urine and 30% with the feces. By inhibiting ACL, bempedoic acid suppresses cholesterol synthesis, 8 thereby triggering the upregulation of LDL receptor expression in the liver, resulting in increased clearance of LDL particles and lowering of LDL-cholesterol in the blood. Please search with another name. [1] Both bempedoic acid and the metabolite are inactivated by glucuronidation of their carboxylic acid groups. 2006-10-25. View Manufacturers, Suppliers & Exporters of Bempedoic Acid API listed on PharmaCompass.com If you have any question, please call our customer This medication works in the liver by blocking an enzyme needed to make LDL. Bempedoic acid was approved for use in the United States in February 2020, and for use in the European Union in April 2020. [1], Bempedoic acid does not interact with the cytochrome P450 enzyme system in the liver and only weakly inhibits the transporter proteins SLCO1B1, SLCO1B3 and SLC22A7 (the latter possibly being responsible for the increase of uric acid in the blood, and therefore the adverse effect gout). It is a drug used for the treatment of high LDL cholesterol, which is … CANADIAN PHARMACY KING | HeFH is an inherited condition that causes high levels of “bad” cholesterol called low density lipoprotein (LDL). Lowering "bad" cholesterol may help to decrease the risk of heart …